Most morphological alterations were presented by the vacuolization of embryonic cells, disintegrated cytoplasm, swollen mitochondria and dilatation in roughendoplasmicreticula.
From theCambridge English Corpus
Mutant cells suffer disruptions in theirendoplasmicreticula, leading to disease.
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Wikipedia
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Thapsigargin raises cytosolic (intracellular) calcium concentration by blocking the ability of the cell to pump calcium into the sarcoplasmic andendoplasmicreticulawhich causes these stores to become depleted.
From
Wikipedia
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